We want to stop the pyrogen test for rabbits

by venus2407 at World Animals Voice shared with thanks

A test on rabbits has been standard for decades to test products for possible contamination by pyrogens.

pyrogen testg

For this, rabbits are fixed in a small box in which they cannot move for several hours, and the test substance is injected into an ear vein. If they develop a fever, the production unit is not released for sale. After a certain “period of use”, the rabbits are killed.

In addition, NON ANIMAL TESTING can be carried out in vitro with greater speed and less expense than by animal experiments.

In 2018, 6,291 rabbits were used in pyrogen tests nationwide. The numbers in the previous years were similarly high.

An animal-free method, the monocyte activation test (MAT), which works with human blood, was developed 30 years ago and internationally validated in 2005.

In 2010 he was included in the European Pharmacopoeia.

One company that carries out the rabbit test is the LS laboratory in Bad Bocklet in northern Bavaria, Germany.
Here more than 82% of the rabbit tests in Germany are carried out.


It can no longer be accepted that even though an animal-free test method is recognized, thousands of rabbits still suffer and die for the pyrogen test in Germany alone.
The rabbit test must be deleted in the European Pharmacopoeia and the approval authorities must prohibit the test!

Please sign the petition: https://www.aerzte-gegen-tierversuche.de/de/helfen/kampagnen/3204

Comment and Information: A rabbit pyrogen test has been used since the 1940s. In this test, the rabbits are locked in full-body holders, then they are injected with a test substance into the blood and their body temperature is monitored. The possible effects on the animals range from fever to breathing problems to fatal shock.

Despite its long use, the rabbit pyrogen test has never been formally reliable to determine its reliability or relevance to humans. Rather, there are a number of well-documented drawbacks to this test, including significant differences in the sensitivity of the species and breed.

In the pharmaceutical industry, pyrogen determination is mandatory to prevent life-threatening fever reactions that can be caused by both microbial and non-microbial substances.

The monocyte activation test (MAT) was included in the European Pharmacopoeia (EP) in 2010 after the publication of international validations.

This test was developed as an alternative to animal-based methods and should offer a possibility to carry out pyrogen tests in a human in vitro system.
In addition, this determination can be carried out in vitro with greater speed and less expense than by animal experiments.

Despite all of these benefits, the Food and Drug Monitoring Agency (FDA) continues to rely on animal testing to assess the pyrogenic potential of new drugs and pharmaceuticals.


Animal testing is a waste of time and money, associated with a high risk of our health.
And with senseless cruelty to animals that exclude ethics and humanity.

Without animal testing, medicine would be much further, because animal testing is stopping medical progress because of its false results.

My best regards to all, Venus

by venus2407 at World Animals Voice shared with thanks


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